ME/CFS RESEARCH FORUM: 26-27 March 2007
University of Adelaide
Convenor: Alison Hunter Memorial Foundation
Butt HL, McGregor NR, Lewis DP, Sheedy JR
’Bacterial Colonosis’ in Patients with Chronic Fatigue Syndrome
Patients with Chronic Fatigue Syndrome (CFS) often report severe symptoms including limited cognitive function, prolonged fatigue, muscle pain, neurological and gastrointestinal symptoms. Gastrointestinal dysfunctions, observed in 61% of a CFS population may suggest the possibility of an altered gastrointestinal microbial flora. A retrospective study of faecal microbiology of 108 well defined CFS patients, examined by one investigator (DPL), was investigated for the period 2005-2006. There were highly significant changes in both the aerobic and anaerobic microbial flora of CFS patients when compared with those from 177 control subjects. A dominance of Gram negative organisms in the faecal microbial flora as seen in the control subjects was significantly shifted to a dominance of Gram positive organisms in CFS patients. Lactic acid was the major metabolites produced by some of the Gram positive organisms from labelled 13C glucose analysed by Nuclear Magnetic Resonance (NMR) over time. The quantitative changes of specific faecal microbial flora in patients with CFS correlated significantly to their symptoms including cognitive dysfunctions, persistent fatigue and pain, and gastrointestinal discomfort.
Bioscreen, Bio21Molecular Science and Biotechnology Institute, University of Melbourne, Victoria.
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