1999 Clinical and Scientific Meeting

Dr Philippe Bottero

Faculte de Medecine,
Paris, France

10 Avenue Henri Rochier
26110 Nyons,

Rickettsia and Chlamydia in Patient Psychopathology - 98 CFS and 79 Other: A Diagnostic and a Therapeutic Report


To determine the probable role of intracellular bacteria like rickettsia and chlamydia in the development of certain chronic psychopathological conditions and determining the efficiency of antibiotic regimes (cyclines or macrolibes).

Because all the patients I have seen since 1981 had a sera reaction positive for rickettsia and chlamydia using the micro-agglutination on blade technique of P and ML Giroud (MAG) by Prof. J.B. Jadin of Antwerp, Belgium with special antigens cultured on guinea pig lungs and chicken embryos.

The great majority of the two groups' patients had vascular problems, both peripheral and central. After Ricketts and Charles Nicolle many writers have shown the clinical and epidemiological importance of the long survival of rickettsia in the reticular endothelial system, the walls of blood vessels and their secretion of vasoconstrictive toxins (GW58).

Since World War II many workers have reported that rickettsia and chlamydia are involved in chronic psychopathologies and have noted concomitant problems of a vascular type (LM61, LM62 and MAS63).

In Palermo (Italy) in 1987, I presented a paper (BOT87) reporting 60 differing cases of "psychopathologies" (with many CFS) treated with antibiotic regimes and associated with rickettsia and chlamydia and circulatory and other problems.


It is an open study which began in 1981 in a private medical practice, not versus placebo, but with random choice. His treatment was for a minimum of six months (cyclines and/or macrolibes together with vasodilatory medication; chloroquine; warm baths).

Group one (98 CFS): women, 78; men, 20; ages of the group, 15 to more than 60 years; for 67 cases the onset of symptoms was more than 2 years previously.

Group two (59 psychosomatic cases; 5 schizophrenia; 3 borderline; 10 children with aggresivity, excitement; 1 autistic child, 1 delerium with relapses. The ages of the group, less than 15 to more than 60 years.


Group one (98 CFS): 79.5% good and very good results, 4.1% fairly good, 16.4% failed. Group two (79 psychopathological cases) 82.3% good and very good results, 2.5% fairly good, 15.2% failed.


This diagnostic and therapeutic study began in 1981 All of Dr Bottero's therapeutic results have been confirmed since 1991 by Dr Cecile Jadin of Randburg (South Africa) for more than 3000 CFS and other psychopathological states (300): Sydney 98 CFS Conference, Australia.

We have shown that rickettsia and chlamydia are probably causative factors in many "psychopathologies". Sometimes associated with other intracellular bacteria (Prof. Nicolson, CA Mycoplasma and CFS) and viral agents becoming reciprocally active and perhaps predetermining genetic factors, and with initial stress which is often observed.

Examples of perjorative associations; mycoplasma and AIDS (Lo, Montagnier); hepatitis B and the agent delta; Burkitt's lymphoma.


Alison Hunter Memorial Foundation
PO Box 6132 North Sydney 2059 Australia
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